I have at least seven 'To Do' lists going at any one time.
First there are the big goals for the year. I personally have nine. Seven are writing related, one is to enjoy/improve the house, and the last is to go do something new and exciting once a month.
Each month I check into those goals. I figure out how my progress has been so far and if the goal still seems relevant and achievable. For 2016 I canceled one of my writing goals that then seemed irrelevant to my bigger goal of becoming an inspirational published writer. I replaced it with a similar goal, learn about the craft of writing, using Brandon Sanderson's class recordings.
I then determine what I should be doing in each goal for the upcoming month. That's the mini goal list. If I look at the big goal too often it feels unachievable. Breaking it up really helps focus.
After that I break it up again, this time into the next step of each goal. Whether it's to buy a plane ticket to go to a new state for a cultural activity, or sit my butt down on the chair and edit the next page, it gets written down on the list.
After that I get to work.
That list becomes the 'number one' important list, but it doesn't hold all of the things that need to get done in every interest in an everyday life. I keep a list of mini goals for author visibility, one for helping out with this LLC, one for the classes I'm taking, one for house upkeep which includes anything from vacuuming to patching the roof, and one for helping out writer friends. They're there, and they get done when I have time, but I know that the 'number one' list is the one I have to spend my time on if I want to succeed in big year long accomplishments.